|
The aim of this project is to provide new fundamental discoveries on surface-mediated biomolecular interactions in their native biological environments. Molecular mechanisms of undesirable nonspecific adhesion of biomolecules and cells to surfaces, i.e. “(bio)fouling”, will be examined at molecular level using tailored low-fouling functional coatings and advanced experimental techniques combined with theoretical predictions. Molecular models of fouling mechanisms will be established based on the extensive study on complex relationships between artificial surface properties and complex real-world biological samples. In addition, based on achieved findings, new concepts to design low-fouling coatings with desired properties to advance biochip technologies in clinical diagnostics, food safety, and security will be pursued.
|